Comparative partial agonist activity of β-adrenoceptor antagonists
نویسندگان
چکیده
منابع مشابه
Prescribing of β-adrenoceptor antagonists in asthma: an observational study.
BACKGROUND β-Antagonists have recently been proposed for the treatment of chronic asthma; however, concerns regarding risk of acute bronchoconstriction in clinical trials remain. OBJECTIVE To determine the frequency of oral β-blocker prescribing in patients with asthma and associations with severe asthma exacerbations requiring oral steroids in patients with active asthma defined by prior ast...
متن کاملAdrenoceptor Antagonists
Drugs that produce responses by interacting with adrenoceptors are referred to as adrenoceptor agonists or adrenergic agonists. Norepinephrine and isoproterenol are examples of such compounds. Agents that inhibit responses mediated by adrenoceptor activation are known as adrenoceptor antagonists, adrenergic antagonists, or adrenergic blocking agents. Prazosin and propranolol are examples of rec...
متن کاملInverse Agonist Activity of 3-Adrenergic Antagonists
Agonist-independent properties of the human f32-adrenergic receptor (fl2AR) were studied using the baculovirus expression system in Sf9 cells. In the absence of agonist but in the presence of GTP, membranes from cells expressing the fl2AR exhibited higher levels of cAMP production than did membranes from uninfected cells or from cells infected with wild-type baculovirus. The increase in cAMP pr...
متن کاملComparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists.
We investigated the relevance of selectivity for a given alpha-1-adrenoceptor subtype for in vivo uroselectivity of several alpha-1-adrenoceptor antagonists (alfuzosin, doxazosin, prazosin, tamsulosin, terazosin and 5-Me-urapidil). Comparison of the affinities of these alpha-1-adrenoceptor antagonists at the cloned alpha-1a, alpha-1b and alpha-1d-adrenoceptor subtypes revealed that tamsulosin a...
متن کاملINFLUENCE OF CCK RECEPTOR AGONIST AND ANTAGONISTS ON TOLERANCE INDUCED TO ANTIPENTYLENETETRAZOL ACTIVITY OF DIAZEPAM
In the present study, the effects of caerulein and CCK receptor antagonist< on tolerance to the anti-pentylenetetrazol activity of diazepam has been studied. Different doses of diazepam (20, 30, 35, 40 and 50 mg/kg) were administered intraperitoneally for a period of 6 days in order to induce tolerance to diazepam. 48 h after the last dose of diazepam, a test dose of diazepam was tested for...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1972
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1972.tb08094.x